Gender Differences in Endothelial Tissue-Type Plasminogen Activator Release in Middle-Aged Adults
نویسندگان
چکیده
منابع مشابه
Gender differences in endothelial tissue-type plasminogen activator release in middle-aged adults.
experience in a small and highly selected patient cohort with a remarkably low-risk profile and a very short time-to-treatment. There is a conflicting evidence about the prognostic significance of prodromal angina associated with pPCI, because someone found a better outcome (7), while others not (8,9). We documented that the additional infarct size reduction associated with prodromal angina tra...
متن کاملTissue-type plasminogen activator release: new frontiers in endothelial function.
Tissue-type plasminogen activator (t-PA) is a pivotal enzyme in the mammalian fibrinolytic system. It exerts its action by converting the zymogen plasminogen into the proteolytically active serine protease plasmin, which, in turn, degrades fibrin clots. Because of its affinity for fibrin, t-PA is the prototypic fibrin-specific plasminogen activator (1). This specificity and its lack of antigeni...
متن کاملEndothelial Tissue-Type Plasminogen Activator Release in Coronary Heart Disease
Objectives. We sought to examine whether the disturbed fibrinolytic system in patients with an acute coronary syndrome is associated with a reduced endothelial fibrinolytic capacity. Background. Intracoronary thrombus formation is a frequent finding in acute coronary syndromes. Systemic alterations of coagulation and fibrinolysis are known to occur, but possible disturbances of endothelial fibr...
متن کاملImpaired endothelial release of tissue-type plasminogen activator in patients with chronic kidney disease and hypertension.
We have shown that the capacity for local release of tissue-type plasminogen activator (tPA) from the vascular endothelium is impaired in patients with primary hypertension. Because this response is an important protective mechanism against intravascular clotting, we investigated whether this system is also defective in patients with advanced chronic kidney disease and hypertension. Nine nondia...
متن کاملBlood pressure reduction and tissue-type plasminogen activator release.
Hypertension is associated with increased risk of thrombotic events including myocardial infarction and stroke. The endothelium plays an important role in limiting intravascular thrombosis, inhibiting coagulation and platelet aggregation, and promoting fibrinolysis. Hrafnkelsdottir et al1 have previously described impaired vascular tissue-type plasminogen activator (t-PA) release in individuals...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2005
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2005.02.025